The Endocannabinoid System

The Endocannabinoid System. 

Endocannabinoid. Say it in your head. Can you say it as one word? It may take a try or two.  

It reminds me of trying to say ambulance or meringue when I was little although the words are complex and hard to say, but really, when you get down to the nitty gritty, the thing itself is quite easy and simple to understand.  


ES, Endocannabinoid System. It is how the body stays healthy. And is the most important physiologic system involved in establishing and maintaining human health. It promotes homeostasis affecting everything from sleep, appetite, pain, inflammation, memory, mood, and even reproduction.  

So, in basic terms, the ES helps modulate the regulation of homeostasis across all major body systems ensuring that all systems work in concert with one another. The Endocannabinoid System plays crucial roles in health and disease outside the brain as-well. 

The first endocannabinoid receptor was identified in the late 1980s and early 90s. The field has been overwhelmingly focused and concentrated on the central nervous system. The main endocannabinoid receptor, CB1, was first discovered in a rat brain and is now known to be among the most abundant G protein–coupled receptors in neurons. 

It is evident that the endocannabinoid system—a family of endogenous ligands, receptors and enzymes—isn’t exclusive to the brain. It is present everywhere in the body that scientists have looked: the heart, liver, pancreas, skin, reproductive tract, you name it. And disrupted endocannabinoid signaling has been associated with many disorders. Including diabetes, hypertension, infertility, liver disease, and more. There is so much that’s still unknown about this system although it looks to be regulating every physiological system in the body. 


There are several different types of cannabinoids. 

Endocannabinoids natural cannabinoids that your body and endocannabinoid system produces on its own. 

Phytocannabinoids produced by the cannabis plant. This includes things like THC (tetrahydrocannabinol), CBD (cannabidiol), CBN (cannabinol) and many more.

Synthetic cannabinoid laboratory produced cannabinoids such as those found in pharmaceutical products like nabilone or sativex and a cannabinoid product can sometimes help you make up a deficiency or lapse within your endocannabinoid system. If your body is not producing enough endocannabinoids then we can sometimes supplement the deficiency with those cannabinoids found in plants or created synthetically.  Both endogenous (created within) and exogenous (external) cannabinoids bind with receptors in the endocannabinoid system.

CB receptors typically found in the brain and throughout the nervous system therefore cannabinoids that target these receptors can have an effect on motor learning and coordination along with pain modulation aswell as metabolism.



Facts about The Endocannabinoid System. 

1. All animals have an endocannabinoid system and so they can benefit from CBD. 

 All animals from mammals to reptiles have an endocannabinoid system so cbd can benefit your and your pets health in the same way.

2. The endocannabinoid system (ES) plays a role in many ailments and diseases. 

The ECS helps bring balance to the body and mind. So it is no surprise that scientists have observed changes in ECS activity in a number of diseases. Everything from neurodegenerative disorders to rheumatoid arthritis and cancer have shown changes in endocannabinoid levels and therefore greater receptor expression. This suggests that the ES may be an effective target for restoring balance in the body and promoting good health. 

3. Exercise and diet may boost the endocannabinoid system (ES). 

Scientists have found that prolonged and ultimately regular aerobic exercise increases levels of anandamide. Which is the “feel good” endocannabinoid therefore diet is also a useful target thus Increasing your intake of the essential fatty acid and omega 3 found in oily fish or healthy seeds like flax or hemp consequently can help support endocannabinoid brain signaling. 


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